Lennart Hilbert, PhD (Physiology), BSc (Physics)

Accepted call as Junior Professor Systems Biology/Bioinformatics
To start in October 2018
Karlsruhe Institute of Technology
Institute of Toxicology and Genetics
Zoological Institute, Faculty of Chemistry and Biosciences

Preferred contact: lennart.hilbert@gmail.com

Publications

Transcription establishes microenvironments that organize euchromatin. Lennart Hilbert, Yuko SatoHiroshi Kimura, Frank Jülicher, Alf Honigmann, Vasily Zaburdaev, Nadine Vastenhouw; bioRxiv preprint, 2017

A tunable refractive index matching medium for live imaging cells, tissues and model organisms. Tobias Boothe, Lennart Hilbert, Michael Heide, Lea Berninger, Wieland B Huttner, Vasily Zaburdaev, Nadine Vastenhouw, Eugene W Myers, David N Drechsel, Jochen C Rink; eLife, 27240, 2017

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. Shai R Joseph, Máté Pálfy, Lennart Hilbert, Mukesh Kumar, Jens Karschau, Vasily Zaburdaev, Andrej Shevchenko, Nadine L Vastenhouw; eLife, 23326, 2017

Computational Study of Synchrony in Fields and Microclusters of Ephaptically Coupled Neurons. Richard Stacey*, Lennart Hilbert*, Thomas Quail; Journal of Neurophysiology, 113:3229-3241, 2015 (*equal contribution)

Phosphate and ADP Differently Inhibit Coordinated Smooth Muscle Myosin Groups. Lennart Hilbert, Zsombor Balassy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 108(3):622-631, 2015

Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin. Lennart Hilbert, Genevieve Bates, Horia N. Roman, Jenna L. Blumenthal, Nedjma B. Zitouni, Apolinary Sobieszek, Michael C. Mackey, Anne-Marie Lauzon; PLoS Computational Biology 9(10): e1003273, 2013

The Kinetics of Mechanically Coupled Myosins Exhibit Group Size Dependent Regimes. Lennart Hilbert, Shivaram Cumarasamy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 105(6):1466-1474, 2013

Unphosphorylated calponin enhances the binding force of unphosphorylated myosin to actin. Horia N. Roman, Nedjma B. Zitouni, Linda Kachmar, Gijs Ijpma, Lennart Hilbert, Oleg Matusovskiy, Andrea Benedetti, Apolinary Sobieszek, Anne-Marie Lauzon; Biochimica et Biophysica Acta (BBA) – General Subjects 1830(10):4634-4641, 2013

Stress-induced hypermutation as a physical property of life, a force of natural selection and its role in four thought experiments. Lennart Hilbert; Physical Biology 10(2):026001, 2013

Pre-Power-Stroke Cross-Bridges Contribute to Force Transients during Imposed Shortening in Isolated Muscle Fibers. Fabio C. Minozzo, Lennart Hilbert, Dilson E. Rassier; PLoS ONE 7(1):e29356, 2012

Small delay, big waves: a minimal delayed negative feedback model captures Escherichia coli single cell SOS kinetics. Lennart Hilbert, David Albrecht, Michael C. Mackey; Molecular Biosystems 7(9):2599-2607, 2011

Education

ELBE Postdoctoral Fellow, Center for Systems Biology Dresden (Nov. 2014 – Sept. 2018)

Supervisor Experiment: Nadine Vastenhouw
Max Planck Institute of Molecular Cell Biology and Genetics

Supervisor Theory: Vasily Zaburdaev
Max Planck Institute for the Physics of Complex Systems

PhD, Physiology, McGill University (Jan. 2010 – Aug. 2014)

Thesis title: “Reverse Engineering Smooth Muscle Molecular Mechanics”
Dept. Physiology, McGill University, Montréal, Québec, Canada
Additional course work: “Bioinformatics Option”

Supervisor Theory: Prof. Michael C. Mackey
Centre for Applied Mathematics in Bioscience and Medicine, McGill University

Supervisor Experiment: Prof. Anne-Marie Lauzon
Meakins-Christie Laboratories, McGill University

Additional inter-departmental training fellowship, 2012-2014
“McGill Systems Biology Graduate Training Program”
Funded by Canadian Institutes of Health Research

Visiting research student (Oct. 2008 – Aug. 2009)

Project work in Mathematical Biology, hosted by Dr. Michael C. Mackey

Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, Montréal, Québec, Canada, Oct. 2008 – Jan. 2009, June – Aug. 2009

Mathematical Institute, University of Oxford, United Kingdom, Jan. – Mar. 2009

BSc, Physics, Bremen University (Nov. 2005 – Oct. 2008)

Dept. Physics, Bremen University, Germany
BSc Thesis in Nonlinear Dynamics and Chaos
Title: “Renormalization theory for Hamiltonian systems”
Thesis Supervisor: Prof. Peter Richter

Publications

A tunable refractive index matching medium for live imaging cells, tissues and model organisms. Tobias Boothe, Lennart Hilbert, Michael Heide, Lea Berninger, Wieland B Huttner, Vasily Zaburdaev,Nadine Vastenhouw, Eugene W Myers, David N Drechsel, Jochen C Rink; eLife, 27240, 2017

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. Shai R Joseph, Máté Pálfy, Lennart Hilbert, Mukesh Kumar, Jens Karschau, Vasily Zaburdaev, Andrej Shevchenko, Nadine L Vastenhouw; eLife, 23326, 2017

Computational Study of Synchrony in Fields and Microclusters of Ephaptically Coupled Neurons. Richard Stacey*, Lennart Hilbert*, Thomas Quail; Journal of Neurophysiology, 113:3229-3241, 2015 (*equal contribution)

Phosphate and ADP Differently Inhibit Coordinated Smooth Muscle Myosin Groups. Lennart Hilbert, Zsombor Balassy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 108(3):622-631, 2015

Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin. Lennart Hilbert, Genevieve Bates, Horia N. Roman, Jenna L. Blumenthal, Nedjma B. Zitouni, Apolinary Sobieszek, Michael C. Mackey, Anne-Marie Lauzon; PLoS Computational Biology 9(10): e1003273, 2013

The Kinetics of Mechanically Coupled Myosins Exhibit Group Size Dependent Regimes. Lennart Hilbert, Shivaram Cumarasamy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 105(6):1466-1474, 2013

Unphosphorylated calponin enhances the binding force of unphosphorylated myosin to actin. Horia N. Roman, Nedjma B. Zitouni, Linda Kachmar, Gijs Ijpma, Lennart Hilbert, Oleg Matusovskiy, Andrea Benedetti, Apolinary Sobieszek, Anne-Marie Lauzon; Biochimica et Biophysica Acta (BBA) – General Subjects 1830(10):4634-4641, 2013

Stress-induced hypermutation as a physical property of life, a force of natural selection and its role in four thought experiments. Lennart Hilbert; Physical Biology 10(2):026001, 2013

Pre-Power-Stroke Cross-Bridges Contribute to Force Transients during Imposed Shortening in Isolated Muscle Fibers. Fabio C. Minozzo, Lennart Hilbert, Dilson E. Rassier; PLoS ONE 7(1):e29356, 2012

Small delay, big waves: a minimal delayed negative feedback model captures Escherichia coli single cell SOS kinetics. Lennart Hilbert, David Albrecht, Michael C. Mackey; Molecular Biosystems 7(9):2599-2607, 2011

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