Lennart Hilbert, PhD (Physiology), BSc (Physics)
ELBE Postdoctoral Fellow, Center for Systems Biology Dresden
Preferred contact: lennart.hilbert[at]gmail.com

Vastenhouw Lab, Max Planck Institute of Molecular Cell Biology and Genetics
Zaburdaev Group, Max Planck Institute for the Physics of Complex Systems

Education

PhD, Physiology, McGill University (Jan. 2010 – Aug. 2014)

Thesis title: “Reverse Engineering Smooth Muscle Molecular Mechanics”
Dept. Physiology, McGill University, Montréal, Québec, Canada
Additional course work: “Bioinformatics Option”

Supervisor Theory: Prof. Michael C. Mackey
Centre for Applied Mathematics in Bioscience and Medicine, McGill University
Supervisor Experiment: Prof. Anne-Marie Lauzon
Meakins-Christie Laboratories, McGill University

Additional inter-departmental training fellowship, 2012-2014
“McGill Systems Biology Graduate Training Program”
Funded by Canadian Institutes of Health Research

Visiting research student (Oct. 2008 – Aug. 2009)

Project work in Mathematical Biology, hosted by Dr. Michael C. Mackey

Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, Montréal, Québec, Canada, Oct. 2008 – Jan. 2009, June – Aug. 2009

Mathematical Institute, University of Oxford, United Kingdom, Jan. – Mar. 2009

BSc, Physics, Bremen University (Nov. 2005 – Oct. 2008)

Dept. Physics, Bremen University, Germany
BSc Thesis in Nonlinear Dynamics and Chaos
Title: “Renormalization theory for Hamiltonian systems”
Thesis Supervisor: Prof. Peter Richter

Publications

A tunable refractive index matching medium for live imaging cells, tissues and model organisms. Tobias Boothe, Lennart Hilbert, Michael Heide, Lea Berninger, Wieland B Huttner, Vasily Zaburdaev,Nadine Vastenhouw, Eugene W Myers, David N Drechsel, Jochen C Rink; eLife, 27240, 2017

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. Shai R Joseph, Máté Pálfy, Lennart Hilbert, Mukesh Kumar, Jens Karschau, Vasily Zaburdaev, Andrej Shevchenko, Nadine L Vastenhouw; eLife, 23326, 2017

Computational Study of Synchrony in Fields and Microclusters of Ephaptically Coupled Neurons. Richard Stacey*, Lennart Hilbert*, Thomas Quail; Journal of Neurophysiology, 113:3229-3241, 2015 (*equal contribution)

Phosphate and ADP Differently Inhibit Coordinated Smooth Muscle Myosin Groups. Lennart Hilbert, Zsombor Balassy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 108(3):622-631, 2015

Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin. Lennart Hilbert, Genevieve Bates, Horia N. Roman, Jenna L. Blumenthal, Nedjma B. Zitouni, Apolinary Sobieszek, Michael C. Mackey, Anne-Marie Lauzon; PLoS Computational Biology 9(10): e1003273, 2013

The Kinetics of Mechanically Coupled Myosins Exhibit Group Size Dependent Regimes. Lennart Hilbert, Shivaram Cumarasamy, Nedjma B. Zitouni, Michael C. Mackey, Anne-Marie Lauzon; Biophysical Journal 105(6):1466-1474, 2013

Unphosphorylated calponin enhances the binding force of unphosphorylated myosin to actin. Horia N. Roman, Nedjma B. Zitouni, Linda Kachmar, Gijs Ijpma, Lennart Hilbert, Oleg Matusovskiy, Andrea Benedetti, Apolinary Sobieszek, Anne-Marie Lauzon; Biochimica et Biophysica Acta (BBA) – General Subjects 1830(10):4634-4641, 2013

Stress-induced hypermutation as a physical property of life, a force of natural selection and its role in four thought experiments. Lennart Hilbert; Physical Biology 10(2):026001, 2013

Pre-Power-Stroke Cross-Bridges Contribute to Force Transients during Imposed Shortening in Isolated Muscle Fibers. Fabio C. Minozzo, Lennart Hilbert, Dilson E. Rassier; PLoS ONE 7(1):e29356, 2012

Small delay, big waves: a minimal delayed negative feedback model captures Escherichia coli single cell SOS kinetics. Lennart Hilbert, David Albrecht, Michael C. Mackey; Molecular Biosystems 7(9):2599-2607, 2011

Selected Conference Talks

Transcription by RNA polymerase II establishes DNA microstructure. Lennart Hilbert*, Yuko Sato, Alf Honigmann, Frank Jülicher, Hiroshi Kimura, Vasily Zaburdaev, Nadine Vastenhouw; *Oral presentation, EMBO Conference “Awakening of the Genome: the Maternal-to-Zygotic Transition”, Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany, 2017

Transcription by RNA polymerase II establishes chromatin microstructure in interphase nuclei. Lennart Hilbert*, Yuko Sato, Alf Honigmann, Frank Jülicher, Hiroshi Kimura, Vasily Zaburdaev, Nadine Vastenhouw; *Oral presentation, Conference “Chromatin and Epigenetics: from Mechanism to Function”, Helmholtz Center Munich, Germany, 2017

Ongoing transcription activity and nuclear RNA accumulation jointly shape chromatin microstructure. Lennart Hilbert*, Yuko Sato, Alf Honigmann, Frank Jülicher, Hiroshi Kimura, Nadine Vastenhouw, Vasily Zaburdaev; *Oral presentation, Physical Biology Circle Meeting, EMBL, Heidelberg, Germany, 2017

Modeling Coordinated Kinetics in Large Groups of Muscle Myosin Motors. Invited talk, Motility and Cytoskeleton Subgroup of the Biophysical Society, Annual Meeting of the Biophysical Society, Los Angeles, USA, 2016

Filamin Inhibition of Myosin Groups Potentiates with Group Size. Zsombor Balassy, Lennart Hilbert*, Nedjma B Zitouni, Anne-Marie Lauzon; *Oral Presentation, Biophysics Subgroup, Spring Proceedings of the German Physical Society, Berlin, Germany, 2015

Dynamical Phenomena in Coupled Muscle Myosins. Lennart Hilbert*, Zsombor Balassy, Shivaram Cumarasamy, Anne-Marie Lauzon, Michael C. Mackey; *Oral Presentation, Biophysics Subgroup, Spring Proceedings of the German Physical Society, Dresden, Germany, 2014

The Minimal Group Size for Globally Coordinated Stepping of Muscle Myosins Depends on ATP Hydrolysis Free Energy. Lennart Hilbert*, Linda Kachmar, Michael C. Mackey, Anne-Marie Lauzon; *Platform Talk, Annual Meeting of the Biophyscial Society, San Francisco, USA, 2014

Additional qualifications

Teaching Experience

Supervision of undergraduate student Zsombor Balassy for a 1 year research project. Research Group Dr. Anne-Marie Lauzon, Meakins-Christie Laboratories, McGill University Health Centre, Fall Term 2013, Winter Term 2014, Summer Term 2014

Teaching Assistant. McGill University,Physics 198-413A: The Physical Basis of Physiology, Fall Term 2013; 3 Credit Course over one Term, Assistance with and Marking of Assignments.

Supervision of undergraduate student Shivaram Cumarasamy for a 1 year research project. Research Group Dr. Anne-Marie Lauzon, Meakins-Christie Laboratories, McGill University Health Centre, Fall Term 2011, Winter Term 2012

Set of six taught lectures “Molecular Motors as a Basic Mechanism of Muscle Contraction”, as part of McGill Physics 413 course “The Physical Basis of Physiology”, Fall Term 2011

Research Visits and Internships

Laboratory visit to the Josh Baker Laboratory, Department of Biochemistry, University of Nevada School of Medicine, Reno, Nevada, USA, Aug. 2012

Stellarator Theory group, Max Planck Institute for Plasma Physics, Greifswald, Germany, Aug. -Sept. 2007

Nonlinear Dynamics group, Physics Department, University Bremen, Germany, Mar. 2006

Bremen Institute for Technology and Society, Bremen, Germany, July – Sept. 2005

Memberships

Biophysical Society
German Physical Society

Selected Awards

ELBE Postdoctoral Fellowship, Center for Systems Biology Dresden, 2014-2016
Oral Presenters First Prize, 20th Annual Graduate Research Day, Department of Physiology, McGill University, 2014
Acceptance into the McGill Systems Biology Training Program (including salary stipend), September 2012 – August 2014
Poster Presentation Prize, 18th Annual Graduate Research Day, Department of Physiology, McGill University, 2012
Graduate Fellowship, Centre for Applied Mathematics in Bioscience and Medicine, 2012
Research Studentship, Research Institute of the McGill University Health Center, awarded consecutively 2010-2011 and 2011-2012
One year traveling studentship, German National Merit Foundation, first awarded 2010, renewal for 2011
J. P. Collip Fellowship, Awarded by the Faculty of Medicine, McGill University, 2010-2011
Student fellow of the German National Merit Foundation, July 2007 – Dec. 2011

Training Courses

“Zebrafish Development and Genetics”, two week practical course, Marine Biological Laboratory, Woods Hole, Aug. 2015

“Montreal Light Microscopy Course”, one week practical course, Advanced BioImaging Facility, McGill University, Mar. 2014

“Information as an Integrating Concept in Science”, two week summer academy on information theory, organized by German National Merit Foundation, Sept. 2010

“From Molecules to Networks”, two week summer academy on Biosystems, organized by German National Merit Foundation, Sept. 2009

“Information as a Currency of Life”, two week summer academy on information theory, organized by German National Merit Foundation, Sept. 2008

Other Positions

Organizing Committee for the McGill Systems Biology Symposium “Systems Biology of Chronic Obstructive Pulmonary Disease”, June 2014

Organizing Committee for the McGill Systems Biology Symposium “Systems Biology of Atherosclerosis”, May 2013

Student representative, Executive Council of the Centre for Applied Mathematics in Biosciences and Medicine, 2012 -2014
Student chapter, Centre for Applied Mathematics in Biosciences and Medicine, 2011 – 2014

Physics student body, Bremen University, 2005 – 2008
Student representative, quality control board “Qualitätszirkel”, Dept. Physics, Bremen University, 2007 – 2008
Student representative in the accreditation of the Physics B.Sc./M.Sc. Curriculum, Bremen University, 2007

Community Service, Aug. 2004 – June 2005
Waldorfkindergarten, Oldenburg, Germany
Assistant to a kindergarten group
Assistant caretaker to a group of pre-kindergarten age children

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