My research addresses conceptual and quantitative questions from the life sciences, with a strong emphasis on the dynamic interaction of nuclear architecture and gene expression. Microscopy of biological samples and mechanistic mathematical models are the main foundations of my work. These are reinforced by custom-programmed image analysis and numerical simulations on small scale or high performance computing infrastructures. Close collaborations are central to my research, ensuring strong connections to current biological questions and recent technological developments as well as access to a wide range of experimental techniques.
Currently, I am working as an ELBE Postdoctoral Fellow at the Center for Systems Biology Dresden (Germany, since 2014), in association with the groups of Nadine Vastenhouw (Max Planck Institute of Molecular Cell Biology and Genetics) and Vasily Zaburdaev (Max Planck Institute for the Physics of Complex Systems). We are investigating how the onset of transcription in zebrafish embryos is connected to the nucleus-wide changes of the spatial organization of DNA.
I obtained my B.Sc. in Physics at Bremen University (Germany, 2005-2008), where I learned basics of dynamical systems theory from Peter Richter. During visits to the Centre for Nonlinear Dynamics in Physiology and Medicine (McGill University, Montreal, Quebec, Canada, 2008-2009) and the Mathematical Institute at Oxford University (United Kingdom, 2009) I got in contact with Mathematical Biology. These visits lead to graduate studies and a Ph.D. in the Department of Physiology, (McGill University, Montreal, Quebec, Canada, 2010-2014). Working in the groups of Michael Mackey (Centre for Applied Mathematics in Biosciences and Medicine) and Anne-Marie Lauzon (Meakins-Christie Laboratories, McGill University Health Centre), I investigated mechanochemical coordination in groups of muscle myosin motors.
Recommended contact: lennart.hilbert[at]gmail.com